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KMID : 0357220080200040035
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Journal of Korean Society Physical Therapy
2008 Volume.20 No. 4 p.35 ~ p.42
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The Hypertensive Vascular Tension-related Signal Transduction and the Relationship of Physical Therapy
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Kim Jung-Hwan
Kim Il-Hyun
Hwang Byoung-Yong
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Abstract
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Purpose: Alterations in the structure and function of vascular smooth muscle cells (VSMCs) are important in cardiovascular disease and maintaining chronic hypertension. Chronic hypertension is associated with changes in vascular smooth muscle tone. The spontaneous or myogenic tone of a blood vessel reflects the ability to adapt smooth muscle tone to changes in transmural pressure. However, the intracellular signaling mechanisms involved in myogenic tone are not fully understood.
Methods: Here, we investigated the relationship between mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3 kinase (PI3K) in isometric contraction and enzymatic activity using muscle strips from rats made hypertensive with aldosterone-analogue deoxycorticosterone acetate (DOCA) salts.
Results: Changes in myogenic tone and intracellular concentration () were different after physiological salt solution (PSS) in normotensive and hypertensive rats. The myogenic tone and quiescent phosphorylation induced by the PSS treatment were inhibited by 10 M PD098059, an extracellular-regulated protein kinase 1/2 (ERK1/2) inhibitor, and 10 M wortmannin, an inhibitor of PI3K, in hypertensive rats.
Conclusion: The development of DOCA-induced hypertension is associated with altered isometric contractions and via changes in activation of ERK1/2 and PI3K after DOCA-salt treatment. Therefore, ERK1/2 and PI3K activity affect hypertension and may be suitable targets for physical therapy in cardiovascular disease.
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KEYWORD
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Hypertension, Mitogen-activated protein kinase, Resting tension
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